Núm. 41 (2021)

EMBL Programme 2017-2021: Digital Biology

41-Azido-41-de­oxy­rapamycin

The title compound, C(51)H(78)N(4)O(12), is a derivative of rapamycin, a triene macrolide anti-biotic mol-ecule isolated from Streptomyces hygroscopicus. The macrocyclic ring structure has 15 chiral centres, with one of the substituent hy-droxy groups giving an intra-molecular hydrogen bond to a ketone O-atom acceptor. The mol-ecules also form inter-molecular hy-droxy-ketone O-H⋯O hydrogen-bond...

Rev_iss_web_ene_13036_23-7 41..41

G. S. Collins and Y. Le Manach Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK, and Departments of Anesthesia and Clinical Epidemiology and Biostatistics, Michael DeGroote School of Medicine, Faculty of Health Sciences, Population Health Research Institute, McMaster University and the Perioperati...

AGI June 41/6

Xiao, Zhi-Qiang, and Adhip P. N. Majumdar. Induction of transcriptional activity of AP-1 and NF-kB in the gastric mucosa during aging. Am J Physiol Gastrointest Liver Physiol 278: G855–G865, 2000.—Although aging enhances expression and tyrosine kinase activity of epidermal growth factor receptor (EGFR) in the gastric mucosa, there is no information about EGFR signaling cascades. We examined the...

AGI May 41/5

Sarna, Sushil K., Asensio Gonzalez, and Robert P. Ryan. Enteric locus of action of prokinetics: ABT-229, motilin, and erythromycin. Am J Physiol Gastrointest Liver Physiol 278: G744–G752, 2000.—We investigated the in vivo and in vitro locus of actions of prokinetics: motilin, erythromycin, and ABT-229. The test substances were infused close intra-arterially in short segments of the jejunum in t...